Mathematical modeling and scale-up of liquid chromatography

the long version

Liquid chromatography has proved to be one of the most important tools for separations. Rapid development in biotechnology has increased the demand for chromatography in analytical, preparative and large scale applications. The understanding of the dynamics of chromatogaphy is imperative for the scale-up. This book is a systematic treatment of the general rate models for various forms of liquid chromatography inluding adsorption, size exclusion, affinity, reversed phase, hydrophobic interaction, and radial flow chromatography. Thermodynamic and mass transfer effects in liquid, chromatography are discussed. Applications of computer programs for the rate models are described and the procedure for the scale-up of preparative and large-scale liquid chromatography using the general rate models are given. Thus the book will be a useful tool for all Biotechnologists, Chemical Engineers, Biochemists, Microbiologists, and other Scientists working with separation techniques.