The HPLC solvent guide

the long version

Solvent selection is perhaps the most commonly overlooked of experimental parameters in high-performance liquid chromatography. When performing separations, even the most experienced analytical chemist tends to select one of three solvents - acetonitrile, methanol, or water - overlooking the fact that many different classes of solvent can be used very effectively in HPLC. By providing extensive detailed coverage of HPLC solvents currently used in a wide range of separations, The HPLC Solvent Guide offers chemists an opportunity to expand their experimental repertoires. The author begins with an in-depth review of the role of solvents in HPLC. This is followed by a series of chapters devoted to the different classes of solvent. To facilitate easy reference, chapters are first grouped by solvent classes, including alcohols, alkanes, ethers, ketones, and nitriles. They are then further divided by field of application (e.g., environmental, pharmaceutical) and by specific analyte class (e.g., priority pollutants, anti-cancer drugs). Throughout, each separation is described as fully as possible, listing the sample matrix, analytes separated and quantified, chromatographic parameters used, and abbreviated results. As a consequence, even novice chromatographers have sufficient information to begin to develop a separation on the basis of a citation alone.